Poison Statistics, National Data, 2016

Reports to U.S. Poison Control Centers

How Many?

In 2016, the 55 U.S. poison control centers provided telephone guidance for nearly 2.159 million human poison exposures.1 That’s about: 

  • 6.6 poison exposures/1000 population,
  • 41.3 poison exposures in children younger than 6 years/1000 children,
  • 1 poison exposure reported to U.S. poison control centers every 14.6 seconds.
 Year: 2016 
 Human Poison Exposures  2,159,032
 Animal Poison Exposures  54,019
 Confirmed Non-Exposures  6,776
 Info Calls - Drug ID  137,880
 Info Calls - Other  352,335
 Total  2,710,042

What Ages are Affected?

While young children (younger than 6 years) comprise a disproportionate percentage of the cases, poisoning affects ALL age groups, from infants to seniors. Peak poisoning frequency occurs in one and two year olds, but poisonings in teens and adults are more serious. Notice that the greater proportion of males in poison exposures occurring in children younger than 13 years switches to a female predominance in teens and adults. 


Across all ages, there were 660 poison exposures reported per 100,000 population. The highest incidence occurred in one and two year olds (8,083 and 7,675 exposures/100,000 children in the respective age groups). For ages 50 years or older, 256 exposures were reported per 100,000 population.1


Children younger than 6 years comprise nearly half of poison exposures (46.4%), followed by adults (39.0%), then teens (7.7%).

2016 age by gender 

Across all ages, 77.8% of poison exposures reported to U.S. poison centers in 2016 were unintentional, 18.1% were intentional, and 2.5% were adverse reactions. In children younger than 6 years, 99.4% of exposures are unintentional, compared to only 33.8% of teen exposures and 59.7% of adult exposures.

Reason by Age Group (2016, column percents)
reason by age 2016 national poisonings 

Most Common Substances Implicated in Poison Exposures?

Cosmetics and personal care products lead the list of the most common substances implicated in pediatric exposures (children younger than 6 years, NPDS, 2016). Cleaning substances and pain medications follow. These exposures are nearly always unintentional.

top 10 pediatric poisonings 2016 national poison data

Pain medications lead the list of the most common substances implicated in adult poison exposures
(20 years old or older, NPDS, 2016). Sedatives and sleeping medications, antidepressants, and cardiovascular medications follow. These exposures are often intentional.

top 10 adult poisonings 2016 national poison data

Most Serious Poisonings?

Frequency statistics are only a part of the poisoning story. To determine where to focus prevention efforts, we also need to know which poisonings are serious.

Fumes/gases/vapors are the single most frequent cause of pediatric fatalities reported to Poison Control. The table below shows poisoning fatalities in children younger than 6 years reported to US Poison Control from 2012 through 2016.

top 10 poisoning deaths 2016 national data

The substance categories with the largest number of deaths across all ages (and including intentional exposures) include sedatives and sleeping medications, opioids, stimulants and street drugs, and alcohols (NPDS, 2016).

How serious are poison exposures?

In 2016, 85% of poison exposures reported to U.S. poison centers were nontoxic, minimally toxic, or had at most a minor effect. (Includes the National Poison Data System codes: no effect; minor effect; not followed, nontoxic; and not followed, minimally toxic.)

medical outcome 2016 national poisonings 

Intentional exposures were significantly more serious, with a 31-fold greater percentage of serious outcomes (major or fatal effects) compared to unintentional exposures. Of the intentional exposures, 5.28% were major effects or deaths compared to 0.17% of unintentional exposures and 1.24% of all exposures. Just 2.77% of unintentional exposures had a moderate, major or fatal outcome compared to 32.59% of intentional exposures and 8.84% of all exposures. 

outcome by reason 2016 npds national poison data 

Exposures in teens and adults were also considerably more serious, with 18.25% of teens and 17.16% of adults having a moderate, major or fatal effect compared to 1.06% of children younger than 6 years. Most exposures in children younger than 6 years (95.85%) were nontoxic, minimally toxic, or had at most a minor effect.

2016 outcome by age 

Many poison exposures can be safely observed at home, without an ER visit. Overall, 66.6% of poison exposures were observed without medical intervention in 2016. For poison exposures occurring in children younger than 6 years, 85.1% were only observed at home (without going to an ER or seeing a physician). In contrast, only 47.1% of adults were managed at the exposure site without medical intervention.

home management by age 2016 national poison data 

These nontoxic or minimally toxic poison exposures that can be safely observed at home are the cases that will most likely be amenable to triage by webPOISONCONTROL®.

Real-time poison exposure data enables surveillance

U.S. poison centers collect data in real time and upload those data every 9.5 minutes (median time to upload). Real-time data are used to find hazardous products quickly, follow substance abuse trends, and detect chem/bioterrorism incidents. Under a grant from the CDC, the American Association of Poison Control Centers and its member poison centers conduct automated, continuous surveillance of poison exposure cases. Alerts are sent when there are an unexpectedly large number of cases in an hour, when there’s an unexpectedly high frequency of a specific symptom, or when there are cases with combinations of clinical effects suggestive of specific poisonings that might require a rapid public health response. Toxicologists promptly investigate these alerts and inform public health officials if outliers are suspicious for events or products of concern.

For more detailed U.S. poison control data, check out the Annual Reports of the American Association of Poison Control Centers:

Other U.S. Poisoning Data Sources

According to the CDC, unintentional poisoning is the leading cause of injury death for all age groups.2 It has surpassed motor vehicle traffic fatalities as the leading cause of injury death in the U.S. since 2008.3 Based on provisional counts, 64,070 cases of death due to drug overdose were recorded in the U.S. in 2016.4 The majority of those cases, approximately 66%, involved an opioid.5 This figure, which includes both prescription opioid and heroin use, is five times higher than the number of opioid overdose deaths reported in 1999.5 The continuous rise in prescribing, use, and abuse of opioid drugs and the subsequent increase in opioid related deaths has come to be known as the opioid epidemic.
Total US Drug Deaths: Provisional counts for 2016 are based on data available for analysis as of 8/2017.
Counts through 2015 are based on final annual data.4
 total US drug deaths

The opioid epidemic was initially fueled by the use of prescription opioids like methadone, oxycodone, and hydrocodone.  Prescribing patterns for opioid medications followed an upward trend from 2006 to 2012.6 Increased awareness, education, and discussion surrounding opioid use has helped to reign in the prescribing habits of many providers and from 2012-2016, opioid prescription rates declined by 4.9% annually.6  

In 2008 it was also reported that the number of deaths involving prescription opioids surpassed the combined number of deaths from both heroin and cocaine use.6 In subsequent years, the number of deaths due to drug overdose, including the number of cases involving opioids, continued to rise. However, by 2015, use of heroin, cocaine, methamphetamines, and synthetic opioids like fentanyl were gaining in popularity. The sharpest rise in drug related fatalities was seen in 2016 and was associated with use of fentanyl and fentanyl analogs with over 20,000 deaths occurring that year.4

drugs involved in US overdose deaths
Drugs involved in US overdose deaths,, 2000 to 2016.

The substantial increase in fentanyl deaths has been linked to illicitly manufactured fentanyl that is used to adulterate other drugs of abuse or sold to unsuspecting users under the guise of another drug name.7 The potency of these synthetic opioids can range from approximately 3-10,000 times the strength of morphine by weight and the adulteration of heroin being sold in the U.S. with synthetic opioids has led to alarming medical consequences like naloxone resistance.8

AAPCC Data Disclosure Statement

Related Links

Summary of Poison Statistics for the Washington, DC region

Summary of National Poison Statistics, Reports to US Poison Centers

The Rise of Medicine in the Home: Implications for Today's Children, SafeKids Worldwide, March 2016

Medicine Safety for Children: An In-Depth Look at Calls to Poison Centers, SafeKids Worldwide, March 2015

Keeping Families Safe Around Medicine, SafeKids Worldwide, March 2014


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