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An apple a day keeps the doctor away. But what about the seeds?

apples and apple seeds

The bottom line

Apple seeds contain amygdalin, a compound that the body converts into cyanide. Cyanide starves oxygen cells. Symptoms may take time to appear because amygdalin must be broken down first. Apple seeds contain very little amygdalin, so swallowing the seeds in an apple core is safe. You would need to chew and swallow a large number of seeds to risk cyanide poisoning.

Prevention tips

  • Eat around apple seeds.

  • Discard the core.

  • Remove apple seeds before using apples in recipes.

  • Avoid ingesting many seeds.

  • Do not chew apple seeds.

  • Remove seeds before giving apples to children.

  • Do not let pets eat apple seeds.

This really happened

A 5-year-old child ingested a whole apple including the seeds. Her mother had read that apple seeds contain cyanide. She called her poison center to check if her son was at risk of cyanide poisoning. The poison center confirmed that he had swallowed seeds from only one apple and that he had no symptoms. The poison center said that this was a non-toxic ingestion and there was no need for any treatment.

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What happens if you swallow apple seeds?

Swallowing a few apple seeds is generally fine. Although they contain a compound that the body can convert to cyanide, the amount is so small that you won’t be at risk unless you deliberately chew and swallow a large quantity.

Are apple seeds poisonous? Do they contain cyanide?

Apple seeds contain amygdalin, which the body breaks down into cyanide. Apple seeds release approximately 0.6 mg of hydrogen cyanide per gram. Cyanide prevents cells from using oxygen. Symptoms of cyanide poisoning include headache, difficulty breathing, fainting, seizures, coma, and cardiovascular collapse. Symptoms may be delayed because the body needs time to convert amygdalin to cyanide.

How many apple seeds can you safely swallow?

The amount of amygdalin in apple seeds is very low, so you would need to swallow many seeds to experience cyanide poisoning. You can safely swallow the number of apple seeds typically present in the core of an apple. The seeds are protected by a hard outer shell. You would need to chew or grind hundreds of seeds and swallow them to release enough hydrogen cyanide to cause toxicity. There is a reported case of death in an adult who chewed and swallowed a cupful of apple seeds.

Do apple seeds have any health benefits?

Apple seed oil contains essential fatty acids, vitamins including vitamin E, and antioxidants. It can be beneficial for skin, hair and nails. On skin it moisturizes, reduces redness and inflammation, reduces wrinkles, and protects the skin from sun. Both its antioxidant effect and enhanced collagen production reduce signs of aging.  It moisturizes and strengthens hair. It can be massaged into nails to increase their strength.

Amygdalin was once promoted as a cancer treatment. Clinical trials found no evidence it works, and it carries a real risk of cyanide toxicity. Its use as a cancer treatment is banned in the US.

What should I do if someone swallows apple seeds?

If someone unintentionally swallows a few apple seeds, there is no need to do anything. If someone ingests a large amount of apple seeds, they are at risk for cyanide poisoning and should be treated in a hospital. If someone swallows apples seeds, or if you have a question about the safety of ingesting apple seeds, use the webPOISONCONTROL online tool to get immediate help, or call your poison center at 1-800-222-1222. Whether online or by phone, expert guidance is always free, confidential, and available 24 hours a day.

References

Barakat H, Aljutaily T, Almujaydil MS, Algheshairy RM, Alhomaid RM, Almutairi AS, Alshimali SI, Abdellatif AAH. Amygdalin: A Review on Its Characteristics, Antioxidant Potential, Gastrointestinal Microbiota Intervention, Anticancer Therapeutic and Mechanisms, Toxicity, and Encapsulation. Biomolecules. 2022 Oct 19;12(10):1514. doi: 10.3390/biom12101514. 

Bolarinwa IF, Orfila C, Morgan MR. Determination of amygdalin in apple seeds, fresh apples and processed apple juices. Food Chem. 2015 Mar 1;170:437-42. doi: 10.1016/j.foodchem.2014.08.083

Cmorej P, Bruthans P, Halamka J, Voriskova I, Peran D. Life-Threatening Cyanide Intoxication after Ingestion of Amygdalin in Prehospital Care. Prehosp Emerg Care. 2022 May-Jun;26(3):455-458. doi: 10.1080/10903127.2021.1924903. 

He XY, Wu LJ, Wang WX, Xie PJ, Chen YH, Wang F. Amygdalin - A pharmacological and toxicological review. J Ethnopharmacol. 2020 May 23;254:112717. doi: 10.1016/j.jep.2020.112717. 

Holzbecher MD, Moss MA, Ellenberger HA. The cyanide content of laetrile preparations, apricot, peach and apple seeds. J Toxicol Clin Toxicol. 1984;22(4):341-7. doi: 10.3109/15563658408992565.

Kristl J, Golenač LP, Sem V. Dynamics of cyanogenic glycosides in apple and plum fruits, products, and byproducts: A concise review. J Food Sci. 2024 Nov;89(11):6839-6862. doi: 10.1111/1750-3841.17377.

Petty L and Forrester MB. Do apple seeds keep the doctor away? Apple seed ingestions reported to poison centers. Clin Toxicol 2019; 57(10):916.

Tian HL, Zhan P, Li KX. Analysis of components and study on antioxidant and antimicrobial activities of oil in apple seeds. Int J Food Sci Nutr. 2010 Jun;61(4):395-403. doi: 10.3109/09637480903535772. 

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