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LSD: Turning on and tuning in, but is it safe?

lsd trip

The bottom line

LSD is a synthetic hallucinogen that changes perceptions and mood. Its effects last 8-12 hours. LSD can impair judgment, leading to dangerous behavior. A bad trip is characterized by a panic reaction with anxiety, fear, and paranoia. Treatment is a quiet, calm space and reassurance. Some people experience flashbacks or hallucinogen persisting perception disorder.

Prevention tips

  • Store LSD up, away, and out of reach of children.

  • Use LSD in a familiar, calm place where you feel secure.

  • Have a friend with you who can provide support and a calming presence.

  • Start with low doses.

  • Stay hydrated.

  • Do not mix LSD with other drugs.

  • Do not drive or operate machinery.

This really happened

A 17-year-old boy used several drugs, primarily LSD, weekly for 4.5 years and then stopped. Five months later he was admitted to a psychiatric unit for suicidal ideation and persistent hallucinatory experiences. These were described as a feeling of euphoria with three-dimensional visions, blurred vision and sometimes seeing black spots in front of his eyes. He stated that food made it worse, so he stopped eating. He was treated with haloperidol, an antipsychotic drug, twice daily. Two days later his symptoms had not improved, so risperidone, another antipsychotic, was added. Two days later he was severely agitated, irritable and combative. He refused to eat or take his medication. He was transferred by his parents to a medical center. He was diagnosed with hallucinogen persisting perception disorder and concurrent depression. He was treated with fluoxetine, an antidepressant, and olanzapine, an antipsychotic. Within 2 weeks he became more sociable, was free of delusions, and had fewer visual hallucinations.

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What is LSD (acid)?

LSD is a synthetic hallucinogen, also known as a psychedelic drug. It is available as drops on blotter paper, tablets, or liquid. Street names include acid, blotter, hits, mellow yellow, microdots, windowpane, and Lucy in the sky with diamonds.

 

What does LSD do to you?

LSD changes the activity of neurotransmitters serotonin and dopamine in the brain. It changes the senses. For example, you hear sounds differently and colors look brighter. Mood changes rapidly and emotions are felt more intensely. Time and space perceptions are changed. Its effects usually last 8–12 hours.

 

Is LSD addictive?

LSD is not addictive. You can stop using it without experiencing physical withdrawal, though it may still be psychologically addicting. You can also develop a tolerance to it, such that it becomes less effective as you continue to use it.

 

What are the dangers of LSD?

While LSD overdoses are rare, it can impair judgment, leading to dangerous behavior such as car accidents or accidental injuries.

Side effects include agitation, anxiety, panic, and paranoia. Other physical effects include dizziness, tremor, muscle weakness, overactive reflexes, increased heart rate, increased temperature, increased blood pressure, sweating, and dilated pupils.

Some people experience flashbacks of the LSD experience. They have a recurring LSD experience characterized by sensory or emotional effects like those experienced when using LSD.  Flashbacks are brief and resolve on their own. Flashbacks are usually benign and pleasant. For some people they cause anxiety, anger, or fear.

Hallucinogen persisting perception disorder (HPPD) is long-term, widespread, and sometimes permanent. Visual disturbances continue and come with an unpleasant, low mood. It is distressing, causes anxiety, and can interfere with daily life. Between 4-5% of people who have used hallucinogens will develop HPPD.

What should I do if someone takes too much LSD?

If someone is experiencing mild symptoms, reassure them that is the symptoms are drug induced and will wear off. Place them in a calm, quiet environment. Make sure they cannot harm themselves. If they have moderate to severe symptoms, including panic, severe psychological distress or significant physical symptoms, seek medical attention right away.

Get expert help

If someone swallows or uses LSD or if you have questions about LSD, use the webPOISONCONTROL online tool to get help, or call your poison center at 1-800-222-1222. Whether online or by phone, expert guidance is always free, confidential, and available 24 hours a day.

What is a bad trip, and what should you do about it?

A bad trip is characterized by a panic reaction in which the person is conscious and oriented but is also anxious, fearful, and paranoid. Other features include bizarre reasoning, self-destructiveness, combativeness, and tearfulness.

You should place the person in a quiet, low-lit environment, reassure the person that they will be all right, and provide relaxation techniques. Benzodiazepines such as lorazepam can be given for agitation and severe anxiety.

 

What happens if a child swallows LSD?

A child will likely not understand why they are seeing things that are not there. This can cause severe distress, panic, agitation, and confusion, as well as sweating, a fast heart rate, high blood pressure, and the other physical effects described above. Seek medical attention right away. 

References

Aldurra G, Crayton JW. Improvement of hallucinogen persisting perception disorder by treatment with a combination of fluoxetine and olanzapine: case report. J Clin Psychopharmacol. 2001;21(3):343-344.

Kurtom M, Henning A, Espiridion ED. Hallucinogen-persisting Perception Disorder in a 21-year-old Man. Cureus. 2019 Feb 14;11(2):e4077. doi: 10.7759/cureus.4077. PMID: 31019855; PMCID: PMC6464987.

Leonard JB, Anderson B, Klein-Schwartz W. Does getting high hurt? Characterization of cases of LSD and psilocybin-containing mushroom exposures to national poison centers between 2000 and 2016. J Psychopharmacol. 2018;32(12):1286-1294.

Lerner AG, Gelkopf M, Skladman I, et al. Flashback and hallucinogen persisting perception disorder: clinical aspects and pharmacological treatment approach. Isr J Psychiatry Relat Sci. 2002;39(2):92-99.

Lerner AG, Lev-Ran S. LSD-associated “Alice in Wonderland syndrome” (AIWS): a hallucinogen persisting perception disorder (HPPD) case report. Isr J Psychiatry Relat Sci. 2015;52(1):67-69.

Martinotti G, Santacroce R, Pettorruso M, et al. Hallucinogen persisting perception disorder: etiology, clinical features, and therapeutic perspectives. Brain Sci. 2018;8(3):47.

Müller F, Kraus E, Holze F, et al. Flashback phenomena after administration of LSD and psilocybin in controlled studies with healthy participants. Psychopharmacology (Berl). 2022;239(6):1933-1943.

Nichols DE, Grob CS. Is LSD toxic? Forensic Sci Int. 2018;284:141-145.

Roberts DM, Premachandra KH, Chan BS, et al. A cluster of lysergic acid diethylamide (LSD) poisonings following insufflation of a white powder sold as cocaine. Clin Toxicol (Phila). 2021;59(11):969-974.

Sabé M, Sulstarova A, Glangetas A, et al. Reconsidering evidence for psychedelic-induced psychosis: an overview of reviews, a systematic review, and meta-analysis of human studies. Mol Psychiatry. 2025;30(3):1223-1255.