Methylsulfonylmethane: a safe treatment for arthritis?

What is methylsulfonylmethane (MSM)?

Methylsulfonylmethane (also known as MSM, or dimethyl sulfone) naturally occurs in several plants, grains, fruits, and vegetables. MSM is an active derivative of DMSO (dimethyl sulfoxide), a laboratory reagent that researchers in the 1960s noted also had antioxidant and anti-inflammatory effect. In the 1970s, two chemists, Drs. Robert Herschler and Stanley Jacob, experimented extensively with MSM to explore possible clinical and therapeutic uses.   In the early 1980s, Dr. Herschler patented MSM for several uses, including skin softening, nail strengthening, and stress relief.

Can MSM help treat arthritis?

There is some evidence supporting that MSM improves stiffness, swelling, and pain from osteoarthritis. Animal and human studies that have investigated MSM’s potential for treating other conditions, like seasonal allergies, range of motion or physical function have not had consistent results.

Although small amounts occur naturally in certain foods, MSM is also synthetically produced, which the easiest way to consume the needed for symptomatic relief. In the US, MSM is sold as a dietary supplement, usually in the form of capsules or powders. It is frequently sold in combination glucosamine and chondroitin. Suggested doses range from 4–6 g orally per day, but doses of up to 20 g per day have been used.

Are there risks associated with taking MSM?

MSM seems to be well tolerated in doses of up to 4 g per day. Common side effects include gastrointestinal upset, skin rashes, and allergic reactions. It is important to keep in mind that as a dietary supplement, MSM is not regulated for safety and effectiveness by the US Food and Drug Administration. If you are considering using MSM, always speak with your physician first and purchase products through trusted and reliable sources.

Potential drug interactions with MSM

There are concerns that MSM might interact with anticoagulants (blood thinners), blood pressure medications, and anti-inflammatory drugs. Ask your pharmacist to do a drug interaction check before taking MSM.

Concerned about an MSM exposure?

If you suspect an adverse reaction to MSM, are concerned about an unintentional overdose, or have a child who might have swallowed some MSM, immediately use the webPOISONCONTROL^® online tool to get additional help or call your poison center at 1-800-222-1222. Whether online or by phone, expert guidance is always free, confidential, and available 24 hours a day.